North and Goessling Labs

Trista North, PhD. and Wolfram Goessling, MD./PhD.

Welcome to the North and Goessling Labs!

Adjusting swimmingly our new labs on the 6th floor of Center for Life Science (BIDMC) and 4th floor of the New Research Building (BWH) at Harvard Medical School. Lots of headway in our newest areas of research, which focus on novel molecular signaling pathways involved in the development and maintenance of the liver and blood system. Using the zebrafish as our model of choice for chemical fishing expeditions, we have started to examine several new leads for conserved regulators of stem cell specification and growth, with the ultimate goal of working toward clinical application to help alleviate human hematopoietic or hepatic disease. learn more >

News

5/15/2009 - Paper Published!
"Hematopoietic Stem Cell Development Is Dependent on Blood Flow". Cell 2009

6/9/2009 - Highlight - Harvard Focus
"Blood Stem Cells Grow with the Flow"

5/13/2009 - Highlight - Harvard Science
"Embryo's heartbeat drives blood stem cell formation"

5/13/2009 - Highlight - Reuters
"Heart beat key for blood growth in embryos: studies"

3/20/2009 - Paper Published!
"Genetic interaction between PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration." Cell 2009

4/3/2009 - Highlight - Cell Stem Cell
"Fishing for a WNT-PGE2 Link: B-Catenin Is Caught in the Stem Cell Net-work"

3/20/2009 - Highlight - Harvard Focus
"Key Regulatory Molecules Interact in Growth and Regrowth of Tissues"

Jobs Available

Post-doctoral and graduate positions are now available! For post-doctoral positions please send a cover letter, CV and 3 letters of reference to both Wolfram and Trista. For graduate positions please send us an email for more information about joining our lab.