Selected Publications

2016

Liu LY, Alexa K, Cortes M, Schatzman-Bone S, Kim AJ, Mukhopadhyay B, Cinar R, Kunos G, North TE, and Goessling W. Cannabinoid receptor signaling regulates liver development and metabolism. Development. 2016.143(4): 609-22.

Moore FE, Garcia EG, Lobbardi R, Jain E, Tang Q, Moore JC, Cortes M, Molodtsov A, Kasheta M, Luo CC, Garcia AJ, Mylvaganam R, Yoder JA, Blackburn JS, Sadreyev RI, Ceol CJ, North TE, Langenau DM. Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. J Exp Med. 2016 May 2. pii: jem.20152013. [Epub ahead of print].

Kwan W, Cortes M, Frost I, Esain V, Theodore LN, Liu S, Budrow N, Goessling W, and North TE. Central Regulation of Glucocorticoid Receptor Signaling via HPA/I Axis Stimulation Controls Embryonic HSPC Production. Cell Stem Cell. 2016.  S1934-5909(16)30154-0.

Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016. S0012-1606(15)30337-7. [Epub ahead of print].

Konantz M, Alghisi E, Müller J, Lenard A. Esain V, Carroll KJ, Kanz L, North TE, Lengerke C. Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. 2016. EMBO J.  Sep 16. pii: e201593454. [Epub ahead of print].

CortesM, Chen MJ, Stachura DL, Liu SY, KwanW, Wright F, Vo L, Theodore LN, EsainV, Frost I, Schlaeger TM, Goessling W, DaleyGQ and North TE. Developmental Vitamin D availability impacts hematopoietic stem cell production. Cell Reports. 2016. 17: 458-468.

Lim SE, Esain V, Kwan W, Theodore LN, Cortes M, Frost IM, Liu SY, and North TE. HIF1a-induced PDGFRb signaling promotes developmental HSC production via IL-6 activation. Experimental Hematology. 2016. (in press).

Reviews:

Kanz D, Konantz M, Alghisi E, North TE, Lengerke C. Endothelial-to-hematopoietic transition: Notch- ing vessels into blood. Ann N Y Acad Sci. 2016 Mar 25. doi: 10.1111/nyas.13030. [Epub ahead of print].

Goessling W, North TE. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell. 2016 Apr 7; 18(4):427-8.

Esain V, Cortes M, North TE. Enumerating Hematopoietic Stem and Progenitor Cells in Zebrafish Embryos. Methods Molecular Biology. 2016. 1451:191-206.

Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen G. Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? Exp Hematol. 2016. S0301-472X(16): 30473-8.

Frame J, Lim SE, North TE. Hematopoietic stem cell development: using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis. Methods in Cell Biology. 2016. (in press).

2015

Esain V, Kwan W, Carroll KJ, Cortes M, Liu SY, Frechette GM, Sheward LM, Nissim S, Goessling W, North TE. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem Cells. 2015 Apr 30.

Cox AG, Goessling W. The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration. Curr Opin Genet Dev. 2015 Apr 6;32:153-161. Review.

Cortes M, Liu SY, Kwan W, Alexa K, Goessling W, North TE. Accumulation of the Vitamin D precursor cholecalciferol antagonizes Hedgehog signaling to impair hemogenic endothelium formation. Stem Cell Reports. 2015. 5(4):471-479.

2014

Goessling W, North TE. Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Dis Model Mech. 2014 Jul;7(7):769-76. Review.

Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TEEstrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27;29(4):437-53.

Cox AG, Goessling WRegenerative biology: Take the brakes off for liver repair. Nature. 2014 Feb 20;506(7488):299-300.

Nissim S, Sherwood RI, Wucherpfennig JSaunders DHarris JMEsain VCarroll KJFrechette GMKim AJHwang KLCutting CCElledge SNorth TEGoessling W. Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth. Developmental Cell. 2014 Feb 24;28(4):423-37.

Li Y*, Esain V*, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE*, Speck NA*. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes and Development. 2014. 29(23): 2597-25612.

Carroll KJ and North TE. Oceans of opportunity: Exploring vertebrate hematopoiesis in the zebrafish model. Experimental Hematology. 2014. 42(8): 684-96.

 

2013

Cox AG, Saunders DC, Kelsey PB Jr, Conway AA, Tesmenitsky Y, Marchini JF, Brown KK, Stamler JS, Colagiovanni DB, Rosenthal GJ, Croce KJ, North TE, Goessling WS-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury. Cell Rep. 2013 Dec 31. pii:S2211-1247(13)00752-3.

Ryan S, Willer J, Marjoram L, Bagwell J, Mankiewicz J, Leshchiner I, Goessling W, Bagnat M, Katsanis N. Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development. 2013 Nov. doi: 10.1242/dev.101170.

Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24. doi: 10.1182/blood-2013-05-503177.

Liu LY, Fox CS, North TE, Goessling WFunctional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Dis Model Mech. 2013 Sep. doi: 10.1242/dmm.011726

Shan J, Schwartz RE, Ross NT, Logan DJ, Thomas D, Duncan SA, North TE, Goessling W, Carpenter AE, Bhatia SN. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug. doi: 10.1038/nchembio.1270.

Wolpin BM, Ng K, Zhu AX, Abrams T, Enzinger PC, McCleary NJ, Schrag D, Kwak EL, Allen JN, Bhargava P, Chan JA, Goessling W, Blaszkowsky LS, Supko JG, Elliot M, Sato K, Regan E, Meyerhardt JA, Fuchs CS. Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer. Oncologist. 2013. doi: 10.1634/theoncologist.2012-0378.

Harris JM, Esain V, Frechette GM, Harris LJ, Cox AG, Cortes M, Garnaas MK, Carroll KJ, Cutting CC, Khan T, Elks PM, Renshaw SA, Dickinson BC, Chang CJ, Murphy MP, Paw BH, Vander Heiden MG, Goessling W, North TE. Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood 2013 Mar 28. doi: 10.1182/blood-2012-12-471201.

2012

Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC. β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell. 2012 Dec 21. doi: 10.1016/j.cell.2012.11.026.

Garnaas MK, Cutting CC, Meyers A, Kelsey PB Jr, Harris JM, North TE, Goessling WRargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol. 2012 Sep 13. pii: S0012-1606(12)00492-7.

Cooney JD, Hildick-Smith GJ, Shafizadeh E, McBride PF, Carroll KJ, Anderson H, Shaw GC, Tamplin OJ, Branco DS, Dalton AJ, Shah DI, Wong C, Gallagher PG, Zon LI, North TE, Paw BH. Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol. 2012 Aug 29. pii: S0012-1606(12)00455-1.

Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR. Mutation mapping and identification by whole-genome sequencing. Genome Res. 2012 Aug;22(8):1541-8.

Goessling WHepatic stellate cells and cirrhosis: Fishing for cures. Hepatology. 2012 Jul 23. doi: 10.1002/hep.25981.

Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 2;209(7):1289-307.

Colanesi S, Taylor KL, Temperley ND, Lundegaard PR, Liu D, North TE, Ishizaki H, Kelsh RN, Patton EE.Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment Cell Melanoma Res. 2012 Mar;25(2):131-43.

2011

Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TEProstaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011 Apr 8;8(4):445-58.

Goessling W, North TEHematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis. Methods Cell Biol. 2011;105:117-36.

North TE, Goessling WEndoderm specification, liver development, and regeneration. Methods Cell Biol. 2011;101:205-23. Review.

2010

North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling WPGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17315-20.

Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26;327(5973):1650-3.

North TE, Goessling WPreviews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice. Cell Stem Cell. 2010 Mar 5;6(3):186-7.

2009

Goessling WDeciphering hepatocellular carcinoma: from bench to bedside and back. Gastroenterology. 2009 Sep;137(3):786-8.

Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Mol Cell Biol. 2009 Jul;29(13):3746-53.

North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15;137(4):736-48.

Goessling W, North TE, Loewer S, Lord AM, Lee S, Stoick-Cooper CL, Weidinger G, Puder M, Daley GQ, Moon RT, Zon LI. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 Mar 20;136(6):1136-47.

2008

Goessling W, Massaro JM, Vasan RS, D'Agostino RB Sr, Ellison RC, Fox CS. Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology. 2008 Dec;135(6):1935-44, 1944.e1. Epub 2008 Sep 20.

Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V. Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene. 2008 Oct 2;27(44):5845-55.

Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008 Aug 1;320(1):161-74.

White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008 Feb 7;2(2):183-9.

2007

Lord AM, North TE, Zon LI. Prostaglandin E2: making more of your marrow. Cell Cycle. 2007 Dec 15;6(24):3054-7. Epub 2007 Oct 3. Review.

Goessling W, North TE, Zon LI. Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nat Methods. 2007 Jul;4(7):551-3.

North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21;447(7147):1007-11.

Goessling W, North TE, Zon LI. New waves of discovery: modeling cancer in zebrafish. J Clin Oncol. 2007 Jun 10;25(17):2473-9. Review.

2006

Goessling W, Mayer RJ. Systemic treatment of patients who have colorectal cancer and inflammatory bowel disease. Gastroenterol Clin North Am. 2006 Sep;35(3):713-27. Review.